20 Best Prescription Flea Medicine For Dogs (2022 Updated)

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Prescription flea medicine for dogs is a medication that is specifically designed to kill fleas and other parasites that may infest your pet. There are many different brands and formulations of this type of medication, so it is important to speak with your veterinarian to determine which one is right for your dog.

Some common active ingredients in these products include fipronil, imidacloprid, and selamectin.

20 Best Prescription Flea Medicine For Dogs

Product Image Product Name Features Price

Vectra 3D, 6 Doses, 21-55 lbs

  • 21-55 lbs 6 Doses

Frontline Plus Flea, Tick & Lice Killer, for Dogs – 3 doses

  • 0.02 oz

Advantage II Flea Treatment for Small Dogs, 4 Monthly Treatments, Size: 3-10lb, White

  • 3-10 lbs

Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses

  • 11-22 lbs

K9 Advantix II

  • Kills fleas on dogs within 12 hours
  • Kills fleas before they lay eggs
  • Kills the flea larvae stage in the dog’s surroundings following contact by a treated dog

Frontline Plus Flea and Tick Control for 23-44 lbs Dogs, 3 Doses

  • 23-44 lbs

Capstar Oral Flea Treatment for Dogs and Cats, Blue, Tablets – 6 count

  • 2-25 lbs

Vectra 3D Blue 3 Dose for Dogs 21-55 lbs

  • Can be used on Dogs and puppies 8 weeks of age and older.
  • Monthly dose repels and kills fleas, ticks, mosquitoes, biting and sand flies, lice and mites (excluding mange mites).

Nexgard Chewable Tablets for Dogs, 4-10 lbs

  • Possible side effects.
  • If you miss giving a dose, give it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Do not double the dose.

Nexgard 60.1-121 lbs 6 Doses for Pets

  • 60.1-121 lbs

Simparica Chewable Tablets for Dogs- 6 Dose- 44.1-88lb

  • 44.1-88.0 lbs

Simparica Trio 11.1-22 lbs. Dogs, 6 Month Supply

  • 11.1-22 lbs

Bravecto for Dogs – Topical Solution – Medium Dogs 22-44 lbs

  • Easy-to-apply topical with fluralaner protects your dog from disease-carrying fleas & ticks
  • Kills adult fleas, treats & prevents flea infestations for up to 12 weeks

Revolution for Dogs

  • Revolution (Brown) for Small Dogs 5-10 kg (10.1 – 20 lbs).
  • Key Benefits.
  • Dosage and Administration.

Credelio (lotilaner) 6 Chewable Tablets for Dogs 25.1-50lbs

  • Once a month beef-flavored chewable tablet that is highly palatable
  • Kills adult fleas and treats flea infestations from Ctenocephalides felis

Revolution for Dogs 0-5 lbs 6 Doses by Zoetis

  • Eliminates fleas treatment and prevention
  • Tick Control
  • Dog Flea Tablets

Simparica 40mg Chewable Tablets for Dogs >10-20 kg (22-44 lbs)

  • Simparica is an easy to eat monthly chewable tablet that fights away fleas, tick, mites and mange.
  • The benefits of Simparica include Kills fleas within 3 hours with a complete kill in 8 hours after treatment.

Comfortis Chewable Tablets for Dogs & Cats, 140 mg – 6 count

  • Comfortis comes in a convenient, beef-flavored chewable
  • Starts to kill fleas within 30 minutes and protection lasts an entire month

Selarid (selamectin) Dogs 5.1-10 lbs 6 Pk

  • 5.1-10 lbs

Bravecto for Dogs – 1 Pack Size: 9.9-22 lbs

  • 9.9-22 lbs / 250 Mg
Vectra 3D, 6 Doses, 21-55 lbs
  • 21-55 lbs 6 Doses
Frontline Plus Flea, Tick & Lice Killer, for Dogs – 3 doses
  • 0.02 oz
Advantage II Flea Treatment for Small Dogs, 4 Monthly Treatments, Size: 3-10lb, White
  • 3-10 lbs
Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses
  • 11-22 lbs
K9 Advantix II
  • Kills fleas on dogs within 12 hours
  • Kills fleas before they lay eggs
  • Kills the flea larvae stage in the dog’s surroundings following contact by a treated dog
Frontline Plus Flea and Tick Control for 23-44 lbs Dogs, 3 Doses
  • 23-44 lbs
Capstar Oral Flea Treatment for Dogs and Cats, Blue, Tablets – 6 count
  • 2-25 lbs
Vectra 3D Blue 3 Dose for Dogs 21-55 lbs
  • Can be used on Dogs and puppies 8 weeks of age and older.
  • Monthly dose repels and kills fleas, ticks, mosquitoes, biting and sand flies, lice and mites (excluding mange mites).
Nexgard Chewable Tablets for Dogs, 4-10 lbs
  • Possible side effects.
  • If you miss giving a dose, give it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Do not double the dose.
Nexgard 60.1-121 lbs 6 Doses for Pets
  • 60.1-121 lbs
Simparica Chewable Tablets for Dogs- 6 Dose- 44.1-88lb
  • 44.1-88.0 lbs
Simparica Trio 11.1-22 lbs. Dogs, 6 Month Supply
  • 11.1-22 lbs
Bravecto for Dogs – Topical Solution – Medium Dogs 22-44 lbs
  • Easy-to-apply topical with fluralaner protects your dog from disease-carrying fleas & ticks
  • Kills adult fleas, treats & prevents flea infestations for up to 12 weeks
Revolution for Dogs
  • Revolution (Brown) for Small Dogs 5-10 kg (10.1 – 20 lbs).
  • Key Benefits.
  • Dosage and Administration.
Credelio (lotilaner) 6 Chewable Tablets for Dogs 25.1-50lbs
  • Once a month beef-flavored chewable tablet that is highly palatable
  • Kills adult fleas and treats flea infestations from Ctenocephalides felis
Revolution for Dogs 0-5 lbs 6 Doses by Zoetis
  • Eliminates fleas treatment and prevention
  • Tick Control
  • Dog Flea Tablets
Simparica 40mg Chewable Tablets for Dogs >10-20 kg (22-44 lbs)
  • Simparica is an easy to eat monthly chewable tablet that fights away fleas, tick, mites and mange.
  • The benefits of Simparica include Kills fleas within 3 hours with a complete kill in 8 hours after treatment.
Comfortis Chewable Tablets for Dogs & Cats, 140 mg – 6 count
  • Comfortis comes in a convenient, beef-flavored chewable
  • Starts to kill fleas within 30 minutes and protection lasts an entire month
Selarid (selamectin) Dogs 5.1-10 lbs 6 Pk
  • 5.1-10 lbs
Bravecto for Dogs – 1 Pack Size: 9.9-22 lbs
  • 9.9-22 lbs / 250 Mg

1. Vectra 3D, 6 Doses, 21-55 lbs

Vectra 3D, 6 Doses, 21-55 lbs

  • 21-55 lbs 6 Doses

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PetCareRx
VIC Pharmacy

Product Details

Specifications

Details
Product Dimensions 5.25 x 1 x 8.5 inches; 0.32 Ounces
Item Package Dimensions L x W x H 8.39 x 5.2 x 0.98 inches
Item Dimensions LxWxH 5.25 x 1 x 8.5 inches
Target Audience Keyword Dogs
Country of Origin United States

Reviews From Real Customers

BigBearsMom
RachelSam
AJG7

2. Frontline Plus Flea, Tick & Lice Killer, for Dogs – 3 doses

Frontline Plus Flea, Tick & Lice Killer, for Dogs - 3 doses

  • Stops flea infestation
  • Kills adult fleas ticks flea eggs and larvae
  • Prevents all flea stages (eggs larvae pupae) from developing
  • Kills ticks that may transmit diseases
  • Provides waterproof effectiveness

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Allivet Pet Pharmacy

Product Details

Specifications

Details
Units in Package 3
Directions See insert for first aid and precautionary statements. It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your pet, read entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Use on dogs only. Do not use on rabbits. Do not use on other animals. To kill fleas, flea eggs & larvae, ticks, and chewing lice apply Frontline Plus for Dogs as follows: To Remove Applicator: Lift and remove the plastic tab to expose foil backing; then peel away the foil. Or use scissors to open. Open applicator. Hold upright with foil side toward you and snap applicator tip. Apply Frontline Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Frontline Plus is approved for use on all dogs, including breeding, pregnant, and lactating bitches and puppies as young as 8 weeks. Frontline Plus remains effective even after bathing, water immersion, or exposure to sunlight. Frequency of Application: When used monthly, Frontline Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply Frontline Plus for 30 days. Frontline Plus kills adult fleas, flea eggs, and flea larvae for up to three months. Frontline Plus also prevents development of all flea stages for up to three months. Frontline Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed. Frontline Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Frontline Plus kills all life stages of ticks (larva, nymph and adult). Frontline Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases. Frontline Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed. Frontline Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.
Ingredients Active Ingredients: Fipronil (9.8%), (S)-Methoprene (8.8%). Inert Ingredients: (81.4%).
Warnings Keep out of reach of children.

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3. Advantage II Flea Treatment for Small Dogs, 4 Monthly Treatments, Size: 3-10lb, White

Advantage II Flea Treatment for Small Dogs, 4 Monthly Treatments, Size: 3-10lb, White

  • 3-10 lbs

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Product Details

Specifications

Details
Product Form Liquid
Animal Type Dog
Product Type Flea Drops
Concentrated No
Active Ingredient Imidacloprid/Pyriproxyfen

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shelly.c
swa Ash
Jethro

4. Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses

Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses

  • 11-22 lbs

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SPC Pets

Product Details

Specifications

Details
Units in Package 3
Unit Size 0.023 fl oz applicators
Directions It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your pet read entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully use on dogs only. Do not use on rabbits. Do not use on other animals. To kill fleas, all stages of brown dog ticks, American dog ticks, lone star ticks, and deer ticks (which may carry Lyme disease) and chewing lice, apply to dogs or puppies (8 weeks or older) as follows: Remove applicator from child-resistant package. Hold applicator upright and snap applicator tip away from face and body. Place applicator tip through animal’s hair to the skin level between the shoulder blades. Squeeze applicator, applying entire contents in a single spot to the animal’s skin. Avoid superficial application to the animal’s hair. Only one applicator per treatment is needed. Frontline Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites. Frontline Plus for Dogs can also be used for the treatment and control of flea, tick and chewing lice infestations on breeding, pregnant and lactating bitches. Frequency of Application: When used monthly, Frontline Plus for Dogs completely breaks the flea life cycle and controls tick and chewing lice infestations. Research demonstrates that Frontline Plus kills adult fleas, flea eggs, and flea larvae for up to three months. Frontline Plus also prevents development of all flea stages for up to three months. Although Frontline Plus can control fleas for up to three months, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed. Frontline Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Frontline Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed. For animal use only.
Ingredients Active Ingredients: Fipronil (9.8%), (S)-Methoprene (8.8%), Inert Ingredients: (81.4%).
Warnings Keep out of reach of children.

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JCar
MeOrTheDog
Kagman

5. K9 Advantix II

K9 Advantix II

  • Kills fleas on dogs within 12 hours
  • Kills fleas before they lay eggs
  • Kills the flea larvae stage in the dog’s surroundings following contact by a treated dog
  • Kills reinfesting fleas in 2 hours

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PetMeds

Product Details

Specifications

Details
Product Form Liquid
Animal Type Dog
Container Size 0.54 oz
Application For Dogs
Application Method Topical

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Maridane
Chuck G
Angelia Lawrence

6. Frontline Plus Flea and Tick Control for 23-44 lbs Dogs, 3 Doses

Frontline Plus Flea and Tick Control for 23-44 lbs Dogs, 3 Doses

  • 23-44 lbs

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Details
Units in Package 3
Directions See insert for first aid and precautionary statements. It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your pet, read entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Use on dogs only. Do not use on rabbits. Do not use on other animals. To kill fleas, flea eggs & larvae, ticks, and chewing lice apply Frontline Plus for Dogs as follows: To Remove Applicator: Lift and remove the plastic tab to expose foil backing; then peel away the foil. Or use scissors to open. Open applicator. Hold upright with foil side toward you and snap applicator tip. Apply Frontline Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Frontline Plus is approved for use on all dogs, including breeding, pregnant, and lactating bitches and puppies as young as 8 weeks. Frontline Plus remains effective even after bathing, water immersion, or exposure to sunlight. Frequency of Application: When used monthly, Frontline Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply Frontline Plus for 30 days. Frontline Plus kills adult fleas, flea eggs, and flea larvae for up to three months. Frontline Plus also prevents development of all flea stages for up to three months. Frontline Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed. Frontline Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Frontline Plus kills all life stages of ticks (larva, nymph and adult). Frontline Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases. Frontline Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed. Frontline Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.
Ingredients Active Ingredients: Fipronil (9.8%), (S)-Methoprene (8.8%). Inert Ingredients: (81.4%).
Warnings Keep out of reach of children.

7. Capstar Oral Flea Treatment for Dogs and Cats, Blue, Tablets – 6 count

Capstar Oral Flea Treatment for Dogs and Cats, Blue, Tablets - 6 count

  • 2-25 lbs

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Product Details

Specifications

Details
Species Body Weight
Dog or Cat 2-25 lbs
Dog 25.1-125 lbs

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8. Vectra 3D Blue 3 Dose for Dogs 21-55 lbs

Vectra 3D Blue 3 Dose for Dogs 21-55 lbs

  • Can be used on Dogs and puppies 8 weeks of age and older.
  • Monthly dose repels and kills fleas, ticks, mosquitoes, biting and sand flies, lice and mites (excluding mange mites).
  • Long Lasting, quick drying, convenient topical treatment with patented applicator. Remains effective after bathing or swimming.
  • Each monthly dose controls development of all flea stages; Prevents, controls and stops flea infestation and prevents re-infestation.

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Product Details

Specifications

Details
Is Discontinued By Manufacturer No
Product Dimensions 2 x 5 x 8 inches; 1.59 Ounces
Item Package Dimensions L x W x H 5.3 x 4.9 x 1.1 inches
Item Dimensions LxWxH 2 x 5 x 8 inches
Target Audience Keyword Dogs
Age Range Description All Stages

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9. Nexgard Chewable Tablets for Dogs, 4-10 lbs

Nexgard Chewable Tablets for Dogs, 4-10 lbs

  • Possible side effects.
  • If you miss giving a dose, give it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Do not double the dose.

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10. Nexgard 60.1-121 lbs 6 Doses for Pets

Nexgard 60.1-121 lbs 6 Doses for Pets

  • 60.1-121 lbs

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Product Details

Specifications

Details
For Use With Dogs
Administration Form Oral
Breed Size Large Breeds
Product Form Chew
Strength 136 mg Afoxolaner

11. Simparica Chewable Tablets for Dogs- 6 Dose- 44.1-88lb

Simparica Chewable Tablets for Dogs- 6 Dose- 44.1-88lb

  • 44.1-88.0 lbs

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Product Details

Specifications

Details
For Use With Dogs
Administration Form Oral
Breed Size Medium Breeds, Large Breeds
Product Form Chewable Tablet
Strength 80 mg Sarolaner

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soraya.h
karly.j
The Pup Mommy

12. Simparica Trio 11.1-22 lbs. Dogs, 6 Month Supply

Simparica Trio 11.1-22 lbs. Dogs, 6 Month Supply

  • 11.1-22 lbs

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Product Details

Specifications

Details
For Use With Dogs
Administration Form Oral
Breed Size Small Breeds
Product Form Chewable Tablet
Drug Type Parasiticide

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DaisysMom
LexYve93
Heather B.

13. Bravecto for Dogs – Topical Solution – Medium Dogs 22-44 lbs

Bravecto for Dogs - Topical Solution - Medium Dogs 22-44 lbs

  • Easy-to-apply topical with fluralaner protects your dog from disease-carrying fleas & ticks
  • Kills adult fleas, treats & prevents flea infestations for up to 12 weeks
  • Treats & controls black-legged tick infestations for up to 12 weeks
  • Treats & controls American dog tick infestations for up to 12 weeks

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Specifications

Details
For Use With Dogs 22-44 lbs. Do not use on dogs under 4.4 lbs
Administration Form Topical
Breed Size Small Breeds, Medium Breeds
Product Form Solution
Strength 500 mg Fluralaner
Drug Type Parasiticide

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Britty
DaveL

14. Revolution for Dogs

Revolution for Dogs

  • 10.1-20 lbs, 6 Month

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Not Happy

15. Credelio (lotilaner) 6 Chewable Tablets for Dogs 25.1-50lbs

Credelio (lotilaner) 6 Chewable Tablets for Dogs 25.1-50lbs

  • Once a month beef-flavored chewable tablet that is highly palatable
  • Kills adult fleas and treats flea infestations from Ctenocephalides felis
  • Starts killing fleas in 4 hours
  • Kills 98.7% of ticks within just 8 hours
  • Approved for dogs 8+ weeks of age, weighing more than 4.4 lbs

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Product Details

Specifications

Details
For Use With Dogs – 8 weeks or older
Administration Form Oral
Breed Size Medium Breeds
Product Form Chewable Tablet
Strength 450 mg Lotilaner
Drug Type Parasiticide

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Lozard
Charity W
JenW

16. Revolution for Dogs 0-5 lbs 6 Doses by Zoetis

Revolution for Dogs 0-5 lbs 6 Doses by Zoetis

  • Eliminates fleas treatment and prevention
  • Tick Control
  • Dog Flea Tablets

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Star 27

17. Simparica 40mg Chewable Tablets for Dogs >10-20 kg (22-44 lbs)

Simparica 40mg Chewable Tablets for Dogs data-lazy-src=

Simparica Chewables are flavoured tablets specifically designed for dogs for their monthly flea and tick protection. The oral tablets start working quickly and remain strong for 35 days without losing its effectiveness.

The fast acting formula starts killing fleas within 3 hours and ticks within 8 hours. When given on regular interval of one month, Simparica offers persistent protection from fleas and ticks.

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Judy Perryman
Tara m
m-marfa-sweoxis

18. Comfortis Chewable Tablets for Dogs & Cats, 140 mg – 6 count

Comfortis Chewable Tablets for Dogs & Cats, 140 mg - 6 count

  • Comfortis comes in a convenient, beef-flavored chewable
  • Starts to kill fleas within 30 minutes and protection lasts an entire month
  • Spinosad, the active ingredient in Comfortis, is environmentally friendly

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Vet Approved RX

Product Details

Specifications

Details
Primary Brand Comfortis
For Pet Weight Max 10 LBS
For Pet Weight Min 4.1 LBS

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donna
Gingi

19. Selarid (selamectin) Dogs 5.1-10 lbs 6 Pk

Selarid (selamectin) Dogs 5.1-10 lbs 6 Pk

  • 5.1-10 lbs

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Allivet Pet Pharmacy
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Product Details

Specifications

Details
Administration Form Topical
For Use With Dogs
Breed Size Extra Small Breeds, Small Breeds
Product Form Liquid
Strength 30 mg Selamectin

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2cats
alizay
Lori Goodson

20. Bravecto for Dogs – 1 Pack Size: 9.9-22 lbs

Bravecto for Dogs - 1 Pack Size: 9.9-22 lbs

  • 9.9-22 lbs / 250 Mg

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Specifications

Details
For Use With Dogs 9.9-22 lbs. Do not use on dogs under 4.4 lbs
Administration Form Oral
Breed Size Small Breeds
Product Form Chew
Strength 250 mg Fluralaner

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Best Prescription Flea Medicine For Dogs Buying Guides

How do these prescription medications work to kill fleas?

There are many types of prescription flea medicines for dogs, but they all work by either killing the fleas directly or by preventing them from reproducing. Some of the most common ingredients in these medications include fipronil, methoprene, and pyriproxyfen.

Fipronil works by causing muscle convulsions and paralysis in the fleas, while methoprene and pyriproxyfen prevent the fleas from reproducing.

How long do they take to work?

It varies depending on the medicine, but most prescription flea medicines for dogs take around 30 minutes to an hour to work.

How often do you need to give them to your dog?

The frequency of administration depends on the specific product prescribed by your veterinarian. Some products are given monthly, while others may be given every 3 months.

What are the possible side effects of these medications?

The possible side effects of these medications of prescription flea medicine for dogs include vomiting, diarrhea, loss of appetite, increased thirst, increased urination, lethargy, weakness, and collapse.

In rare cases, these medications can cause seizures and death.

How much do they cost?

The cost of prescription flea medicine for dogs can vary depending on the type of medicine, the dosage, and the size of the dog. However, on average, the cost of prescription flea medicine for dogs is between $30 and $50.

Where can you get them?

The best place to get prescription flea medicine for dogs is from your veterinarian. They will be able to recommend the best product for your dog based on their health and lifestyle.

What are the pros and cons of using prescription flea medicine for dogs?

There are many pros and cons to using prescription flea medicine for dogs. Some pros include that it can help to kill fleas and ticks on your dog, and it can also help to prevent future infestations.

Additionally, it can be used as aspot-on treatment, which means that you can target specific areas on your dog’s body where fleas are present. However, some cons to using prescription flea medicine include that it can be toxic to dogs if not used properly, and it can also be expensive.

Additionally, some dogs may be allergic to the ingredients in the medication, which can cause adverse reactions.

Are there any natural alternatives to prescription flea medicine for dogs?

There are a few natural alternatives to prescription flea medicine for dogs. Some people use essential oils, like lavender or eucalyptus, which can repel fleas. Others add brewer’s yeast or garlic to their dog’s food, which can make the dog’s blood less attractive to fleas.

There are also natural topical treatments, like rosemary or lemon oil, which can be applied directly to the dog’s fur.

Conclusion

The conclusion of prescription flea medicine for dogs is that it is an effective way to protect your pet from fleas.

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