Best Methylfolate Supplement For Mthfr (2024 Updated)

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If you are looking for the best methylfolate supplement for MTHFR, you are likely aware of the importance of this nutrient for your overall health. Methylfolate is the active form of folate, which is essential for DNA synthesis, red blood cell formation, and neurotransmitter production. However, people with MTHFR gene mutations may have difficulty converting folate into methylfolate, which can lead to a range of health problems, including cardiovascular disease, depression, and neural tube defects in pregnancy.

To ensure that you are getting the best methylfolate supplement for your needs, there are several key points to consider. First, you should look for a supplement that contains the active form of methylfolate, rather than folic acid or other folate derivatives. You should also check the dosage of the supplement, as some people may require higher doses of methylfolate depending on their MTHFR genotype and other health factors.

Other important factors to consider when choosing a methylfolate supplement include the quality and purity of the ingredients, the form of the supplement (e.g. capsule, tablet, sublingual), and any potential interactions with other medications or supplements you may be taking. Additionally, you may want to look for a supplement that is vegan, gluten-free, and free of artificial colors, flavors, and preservatives.

Overall, finding the best methylfolate supplement for MTHFR requires careful research and consideration of your individual health needs. By taking the time to choose a high-quality supplement that meets your specific requirements, you can support your overall health and wellbeing.

10 Best Methylfolate Supplement For Mthfr

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1. Md. Life L-Methylfolate 15mg Is A Doctor-Designed, Vegan Supplement That Provides Maximum Strength Active Folate. It Contains Essential Amino Acids And Methylated Folate In 90 Capsules.

MD Life's L-Methylfolate 15 mg is a doctor-designed active folate supplement designed to support healthy cell production and repair. Unlike folic acid, which requires conversion by the MTHFR enzyme, L-Methylfolate is the already converted form of folate that the body can easily use.

This essential amino acid plays a crucial role in the synthesis and repair of new cells, making it a vital nutrient for overall health and wellness. Unfortunately, up to half of the US population may have difficulty converting folic acid into its active form, making supplementation with L-Methylfolate 15 mg an important consideration for many people.

MD Life's L-Methylfolate 15 mg is third-party tested for purity, ensuring the highest level of quality and safety for consumers. These supplements are made and packaged in the USA, further ensuring their quality and purity.

In addition to supporting healthy cell production and repair, L-Methylfolate 15 mg is also a great choice for mood and brain support. Sleep, concentration, energy, mood stability, and hormone support can all be assisted by this nutrient.

MD Life offers a range of potent doses of L-Methylfolate, with the 15 mg dose being the most powerful. This professional-strength supplement provides a big difference that consumers can see and feel.

Overall, MD Life's L-Methylfolate 15 mg is an active folate supplement that is crucial for healthy cell production and repair, mood and brain support, and overall wellness. With its professional-strength dose and third-party testing for purity, this supplement is a top choice for anyone looking to support their health and wellbeing.

2. Codeage Methylfolate B Complex: 5-Mthf, Methylcobalamin, Riboflavin, Betaine, B6, Methylation Cycle Support – 2 Months Supply (120 Capsules)

Codeage Methylfolate B Complex Supplements are an all-in-one methylation supplement that contains folate, methylated vitamins, riboflavin, and betaine in an easy to use capsule format. This innovative formula offers an active form of folate and vitamins B2, B6, B12, making it an ideal choice for individuals with methylation cycle issues or MTHFR mutations.

Methylfolate B Complex contains 1360 mcg of 5- MTHF folate with Quatrefolic 5 methylfolate and glucosamine salt as a folate supplement. This methylation formula also contains 30 mg of Riboflavin 5’- Phosphate as a riboflavin supplement. These two ingredients are essential for optimal methylation and DNA synthesis.

Additionally, this formula features 600 mg of betaine as trimethylglycine (TMG). Betaine is a powerful methyl donor that helps to support the methylation cycle and reduce homocysteine levels. This can help to improve cardiovascular health and reduce the risk of heart disease.

One of the unique features of Codeage Methylfolate B Complex is that it contains methylated forms of folate and vitamins B2, B6, B12. This means that the vitamins included in this formula (vitamin B6 and vitamin B12 1000 mcg) are provided in their phosphorylated forms, which are more easily utilized by the body.

This advanced formula is also vegan, gluten-free, non-GMO, and made in the USA. Codeage methylated vitamins capsules are manufactured in a cGMP certified facility and are third-party tested for purity and potency. Each bottle contains 120 capsules, providing a 2-month supply of this essential supplement.

In summary, Codeage Methylfolate B Complex Supplements offer a comprehensive approach to methylation support, providing an active form of folate and methylated vitamins B2, B6, B12, riboflavin, and betaine. This formula is vegan, gluten-free, non-GMO, and made in the USA, making it a safe and effective choice for individuals looking to support their methylation cycle and overall health.

3. Life Strength L-Methylfolate 5 Mg: Optimized & Bioactive 5-Mthf Supplement For Mood, Immune Support, & Energy. Non-Gmo & Gluten-Free. 90 Capsules.

Life Strength L-Methylfolate 5 MG is a dietary supplement that contains highly bioavailable and active folate. This supplement is optimized for the body to properly utilize folic acid, which is also known as a complex B9 vitamin. Unlike folic acid, which is the synthetic form of vitamin B9, methyl folate is the already converted form of folate that people can easily use without the MTHFR enzyme.

Methylfolate is essential for DNA synthesis and cell repair. It helps in the production and maintenance of new cells and may also help in the synthesis of DNA and RNA. Methyl folate can also help in the production of healthy red blood cells and is critical during periods of rapid growth, such as during pregnancy and fetal development.

This supplement is also beneficial for brain and mood support. Methylfolate can help in neurotransmitters production that is responsible for concentration, sleep, energy, hormones, and mood stability. It may improve cognitive performance, slow down deterioration caused by aging, and help maintain brain health.

Furthermore, Life Strength L-Methylfolate 5 MG may support cardiovascular health. Folate acid may help break down homocysteine, an amino acid that may damage the inner walls of arteries. This supplement may help stimulate heart health and healthy peripheral nerve function by supporting already healthy homocysteine levels and nitric oxide production.

Life Strength L-Methylfolate 5 MG is made in the USA in a GMP facility. It is formulated using the finest ingredients sourced and formulated by Dr. Berto Lopez MD, who studied Vitamins for over 45 years in Palm Beach Florida. Our supplement is made in our state-of-the-art facilities using non-GMO, plant-based, and gluten-free ingredients and third-party tested for your peace of mind.

In conclusion, Life Strength L-Methylfolate 5 MG is a natural diet supplement that provides energy, mood support, and immune system support. It is highly bioactive and optimized for the body to properly utilize folic acid. This supplement is made using the finest ingredients and is third-party tested for quality and purity.

4. Homocystex Plus: Active B Complex Supplement For Homocysteine & Methylation Support, Mthfr Gene & Vegetarian, 60 Capsules.

Seeking Health HomocysteX Plus is a comprehensive vitamin supplement designed to support the homocysteine pathway and methylation. It contains a blend of active B complex vitamins, including folate (as L-methylfolate), vitamin B12 (methylcobalamin & adenosylcobalamin), and P-5-P (pyridoxal 5’-phosphate), as well as R-5-P (riboflavin 5’-phosphate). Together, these ingredients work synergistically to balance homocysteine levels and support overall health.

This formula is especially ideal for individuals with the MTHFR gene mutation, as it contains additional Betaine (TMG) to support methylation not only via MTHFR, but also via the BHMT gene. Furthermore, the targeted active ingredients in HomocysteX Plus support all other homocysteine genes, making it an excellent choice for anyone looking to promote optimal health.

In addition to supporting healthy homocysteine levels and methylation, HomocysteX Plus offers a range of other health benefits. The vitamin B complex helps to balance nitric oxide levels, which may contribute to healthy blood pressure. The addition of adenosylcobalamin also supports nerve health, making this supplement a great choice for individuals looking to support their overall wellbeing.

One of the standout features of HomocysteX Plus is its commitment to quality. At Seeking Health, every ingredient is carefully sourced, researched, and tested to ensure consistent quality and efficacy. The supplement is free from a range of common allergens, including eggs, fish, gluten, GMOs, milk, peanuts, shellfish, soy, tree nuts, and wheat. It also contains no artificial colors, flavors, or preservatives, making it a natural choice for anyone looking for a high-quality vitamin supplement.

In summary, Seeking Health HomocysteX Plus is a comprehensive and high-quality vitamin supplement designed to support the homocysteine pathway, methylation, and overall health. Its targeted active ingredients and commitment to quality make it an excellent choice for anyone looking to promote optimal wellbeing.

5. Physician-Designed Mthfr Renew Supplement With B Complex, Methyl Folate, Zinc, And Vitamin B12 For Energy Support, Heart Health, And Methylation Support.

PD VARS Physician Designed MTHFR Renew Supplement is a revolutionary product that has been formulated to provide error pathways correction, improve energy and mood, support methylation, homocysteine and cardiovascular health. The supplement is great for both women and men and is made of pure pharmaceutical grade encapsulation for optimum use by the body. The easy to swallow capsule eliminates the hassle of liquid drops, gummies or powder.

MTHFR Support is formulated to provide support for MTHFR genetic errors as it utilizes intracellular vitamin and amino acid deficiencies. The MTHFR gene helps convert folic acid into an active form, methylfolate. Activated folate can treat low levels. The supplement restores methylation activity, a process required by many of the body's systems. MTHFR Support helps restore methylation effectively and efficiently. The supplement is clinically proven and made in USA laboratories with the latest research and pharmaceutical findings.

The supplement contains a vitamin B complex formula, including vitamins B6, folate as methyl methyltetrahydrofolic acid, glucosamine salt, B12 as methylcobalamin, B5, zinc, N-Aceytl L Cysteine, Trimethyl Glycine, N-Aceytl L-Tyrosine and L-Glutamine, and more essentials. This optimal blend promotes overall wellness.

The product is easy to use, simply take a dose of 2 pills per day or as directed by physicians. Regular maintenance is important to avoid fatigue and pain. Each pill contains bioavailable folate, as well as other key multivitamins. It is super for adults who want an integrative, therapeutic approach to health.

PD VARS Physician Designed MTHFR Renew Supplement provides many benefits, including error pathways correction, improved energy and mood, methylation, homocysteine and cardiovascular health. The supplement is designed to help individuals with MTHFR genetic errors by utilizing intracellular vitamin and amino acid deficiencies. The supplement is also clinically proven and made in USA laboratories with the latest research and pharmaceutical findings. The vitamin B complex formula promotes overall wellness and is easy to use. The supplement is a great choice for adults who want an integrative, therapeutic approach to health.

6. Intelligent Labs Mthf L-5-Methyltetrahydrofolate Supplement With Quatrefolic Acid – 60 Capsules, 2 Months Supply, 5mg Methylfolate For Women And Men.

Intelligent Labs 5MG MTHF L-5-Methyltetrahydrofolate Activated Folic Acid Supplement is an advanced folate supplement that contains Quatrefolic Acid, the 4th generation activated folate. It is a stable, pure, and better-absorbed form of 5-MTHF that is bound to glucosamine instead of calcium. Each bottle contains 60 capsules that provide a 2-month supply of 5mg (5000mcg) Methylfolate for both men and women.

For individuals with an MTHFR problem, this supplement may be beneficial. It uses the scientifically advanced 5-MTHF Quatrefolic Acid, internationally patented by Gnosis, to ensure high-quality and effective results. The supplement is also referred to as 6 (S)-L-MTHF, L-5, and chemically similar to metafolin or l-methylfolate calcium, except the methylfolate is bound to glucosamine (non-shellfish derived) instead of calcium. This ensures that the supplement is suitable for individuals who need to avoid shellfish-derived products.

Each vegetarian capsule contains 1mg of activated folic acid, making it a high-strength supplement. Folate supplementation contributes to the reduction of tiredness and fatigue, normal homocysteine metabolism, normal psychological and immune system function, and increases maternal folate status, which reduces the risk of neural tube defects in babies.

Intelligent Labs prioritizes quality and ensures that their health products do not contain artificial flavors, additives, or preservatives. They have third-party testing certificates available for all customers to see, ensuring that the supplement is of high quality and purity. The 5-MTHF supplement is manufactured at an NSF GMP-certified facility in the United States to ensure quality and purity.

In summary, Intelligent Labs 5MG MTHF L-5-Methyltetrahydrofolate Activated Folic Acid Supplement is an excellent choice for individuals looking for a high-strength, high-quality, and effective folate supplement. It contains Quatrefolic Acid, the 4th generation activated folate, which is stable, pure, and better absorbed than other 5-MTHF supplements. It is suitable for individuals with an MTHFR problem and those who need to avoid shellfish-derived products. The supplement contributes to various health benefits, including reducing tiredness and fatigue, improving homocysteine metabolism, and increasing maternal folate status.

7. Prenatal Supplement With Optimized Folate For Healthy Pregnancy And Dna Synthesis. Includes Vitamin C, B And Iron. 1 Month Supply.

MTHFR Support Prenatal Methyl Folate is a specialized prenatal vitamin and mineral supplement that is designed to provide optimum support for DNA synthesis and healthy pregnancy. It is formulated specifically for those with MTHFR polymorphisms who face challenges in folate absorption and utilization.

This supplement contains an active methyl folate formulation that delivers a superior form of folate that is more readily absorbed by the body than folic acid. Folate deficiency due to MTHFR polymorphisms can increase the risk of miscarriage, but this risk is greatly reduced by taking the right form and dose of folate.

The MTHFR Support Prenatal Methyl Folate supplement is carefully balanced to deliver the right amount of key nutrients that are critical for a healthy pregnancy. These include Active Methylfolate, Choline, Iodine & Selenium, Vitamin E Isomers as Tocotrienol, Chromium, Vitamin C, MTHFR B Complex, & Chelated Minerals Zinc, Copper, Manganese, Molybdenum, & Iron.

In addition to delivering a carefully balanced set of essential nutrients, this supplement is also free of gluten, dairy, soy, and genetically modified ingredients. It does not contain any of the additives typically found in mainstream prenatal supplements.

Each pack of MTHFR Support Prenatal Methyl Folate includes a Prenatal multivitamin (2 caps), EPA & DHA essential fatty acids (2 caps), Choline for fetal brain development (2 caps), and Acetyl L carnitine for energy (1 cap). This makes it easy to get all the essential nutrients you need in one convenient package.

Overall, MTHFR Support Prenatal Methyl Folate is an ideal prenatal supplement for those with MTHFR polymorphisms. Its proprietary formulation provides active folate and other essential nutrients to aid DNA synthesis for quality sperm and egg development, while the balance of key nutrients critical for a healthy pregnancy helps to ensure that both mother and baby receive the support they need.

8. Md. Life L-Methylfolate 10mg – A Professional-Grade Supplement With Active Folate To Support Mthfr Function, Essential Amino Acids, And Brain Health. 30 Vegan Capsules.

MD. Life L-Methylfolate 10 mg is a professional strength methyl folate supplement that supports the active folate 5 MTHFR. This formula contains the necessary ingredients to aid the body in properly utilizing folic acid, also known as a complex b9 vitamin. Unlike folic acid, which is a synthetic form of vitamin B9, methylfolate is the already converted form of folate that the body can easily use without the need of the MTHFR enzyme.

The most active form of methylfolate, 10 mg, is essential in the production and maintenance of new cells. This supplement supports the synthesis and repair of cells in the body, making it a great choice for those who want to maintain optimal cell health.

MD Life's Methylfolate 10mg supplement is third-party tested for purity, ensuring that the highest level of quality and purity is maintained in the manufacturing of the product. Third-party certification means that these products comply with specific standards set for safety, quality, and performance. The supplement is made and packaged in the USA, which further ensures its quality and safety.

Methylfolate 10mg also aids in mood and brain support. The supplement is a great choice for those who need mood support, as it helps with sleep, concentration, energy, mood stability, and hormone support. The active folate 5 MTHFR in the supplement also supports brain health, making it an essential amino acid supplement.

In conclusion, MD. Life L-Methylfolate 10 mg is a professional strength methyl folate supplement that supports active folate 5 MTHFR. This supplement aids in the production and maintenance of new cells, ensuring optimal cell health. Third-party testing ensures the highest level of quality and purity, and the supplement is made and packaged in the USA. Methylfolate 10mg also aids in mood and brain support, making it an essential supplement for those who want to maintain their overall health and well-being.

9. Md. Life L-Methylfolate 2.5mg Vegan Capsules – Professional Strength Mthfr Support Supplement For Brain & Amino Acid Essentiality – 90ct

MD. Life L-Methylfolate 2.5 mg is a professional strength supplement that provides active folate support to individuals who may have difficulty converting folate into its active form. This supplement contains essential amino acids and is a brain supplement that supports mood, concentration, energy, and hormone balance.

The active ingredient in this supplement is L methylfolate 2.5mg, which is the already converted form of folate that the body can easily use without the need of the MTHFR enzyme. Unlike folic acid, which is the synthetic form of vitamin B9, methylfolate is quickly absorbed and utilized by the body.

Methylfolate is essential for the production and maintenance of new cells, making it a crucial nutrient for overall health. About half of the population in the United States may have difficulty converting folate into its active form, which is why a supplement like MD. Life L-Methylfolate 2.5 mg is necessary for proper folate utilization.

All MD. Life supplements undergo extensive third-party lab testing to ensure the highest level of quality and purity in the manufacturing process. Third-party certification ensures that these products comply with safety, quality, and performance standards. Additionally, these products are made and packaged in the USA.

MD. Life's Methylfolate 2.5mg is a great choice for mood support. This supplement can assist with sleep, concentration, energy, mood stability, and hormone support as it is the only folate that has been known to cross the blood-brain barrier.

This supplement is designed by doctors to provide a professional strength dose of L methylfolate. Many other L-methylfolate products contain small amounts, but MD. Life offers a wide range of potent doses to ensure a big difference that you can see.

In summary, MD. Life L-Methylfolate 2.5 mg is a professional strength supplement that provides active folate support to individuals who may have difficulty converting folate into its active form. This supplement is third-party tested for purity and is made and packaged in the USA. It supports mood, concentration, energy, and hormone balance, and is designed by doctors to provide a potent dose of L methylfolate.

10. Mthfr Support Supplement – Vitamin B Complex With Magnesium, Vitamin D3, Methyl B12, And Methylfolate.

The Vitamin B Complex with Vitamins B6 20mg, D3 1000IU, Albion Magnesium Bisglycinate 260mg, Methyl B12 1000mcg, and Folate as Methylfolate 600mcg DFE is a doctor-formulated supplement that supports the NEURO and BRAIN functions of the body. The supplement is designed to improve stamina, mood, and energy production, making it ideal for individuals experiencing fatigue or low energy levels.

The supplement contains B6 as Pyridoxal-5-Phosphate 20mg, B12 as Methylcobalamin 1000mcg, D3 1000IU, Albion Magnesium Bisglycinate 26mg, and Folate 600mcg DFE. These ingredients work together to support the cognitive function and energy production of the body. Additionally, the supplement contains Vitamin D3, which supports immune system health.

Vitamin B deficiency is often associated with Vitamin D deficiency. Magnesium regulates vitamin B and D3 absorption. The supplement contains Albion Magnesium Bisglycinate, which is the most bioavailable form of magnesium. This form of magnesium is not ionized in the gut, making it less likely to cause intestinal distress. It also helps regulate the absorption of Vitamins B and D.

The supplement contains Folate (Metafolin L-5-MTHF), which is not Folic Acid. Folate is ideal for individuals with MTHFR gene expression, as it aids in cognitive function support and promotes the best absorption of B Vitamins.

The Vitamin B Complex with Vitamins B6 20mg, D3 1000IU, Albion Magnesium Bisglycinate 260mg, Methyl B12 1000mcg, and Folate as Methylfolate 600mcg DFE is formulated for individuals who experience fatigue, low energy levels, and methylation difficulties. It is also ideal for individuals with MTHFR traits. The supplement is made in the USA without Magnesium Stearate, Silicon Dioxide, or Titanium Dioxide.

Overall, the Vitamin B Complex with Vitamins B6 20mg, D3 1000IU, Albion Magnesium Bisglycinate 260mg, Methyl B12 1000mcg, and Folate as Methylfolate 600mcg DFE is a doctor-formulated supplement designed to improve the NEURO and BRAIN functions of the body. It is ideal for individuals experiencing fatigue, low energy levels, and methylation difficulties, and it supports cognitive function, energy production, and immune system health.

Best Methylfolate Supplement For Mthfr FAQs

Are there any potential side effects or interactions to be aware of when taking a methylfolate supplement for MTHFR?

Yes, there are potential side effects and interactions to be aware of when taking a methylfolate supplement for MTHFR. The most common side effects of methylfolate supplementation include digestive issues such as nausea, bloating, and diarrhea. In some cases, high doses of methylfolate may cause skin rashes, sleep disturbances, and irritability. Additionally, people taking certain medications such as antiepileptic drugs, methotrexate, and some antibiotics should use caution when taking methylfolate supplements as it may interact with these medications and reduce their effectiveness. It is important to consult a healthcare professional before starting any new supplement regimen, especially if you have a medical condition or are taking any medications. They can help determine the appropriate dosage and monitor any potential side effects or interactions.

How do I choose the best methylfolate supplement for my specific MTHFR genotype?

Consult with a healthcare professional to determine your MTHFR genotype and decide on the appropriate methylfolate supplement dosage. In general, methylfolate supplements come in varying doses, so it is important to select a supplement that fits your specific needs. You may also want to consider supplements that contain other B vitamins, as they are important for methylation pathways in the body. Look for supplements that are free of fillers, binders, and artificial additives, and choose a reputable brand with good reviews. Keep in mind that some people may experience side effects from taking methylfolate, including headaches, nausea, and anxiety, so it is important to start with a low dose and gradually increase as tolerated. Lastly, remember that supplements should not replace a healthy diet and lifestyle, so be sure to prioritize these aspects of your health as well.

What are the key factors to consider when selecting a methylfolate supplement for MTHFR support?

When selecting a methylfolate supplement for MTHFR support, it is important to consider several key factors. These include:

1. Form of methylfolate: Choose a supplement that contains methylfolate in its active form, as this will ensure maximum absorption and effectiveness.

2. Dosage: The dosage of methylfolate should be appropriate for your individual needs and health status. Consult with a healthcare practitioner to determine the correct dosage.

3. Quality: Look for a supplement that is made by a reputable company and has been third-party tested for purity and quality.

4. Additional ingredients: Check the supplement label for any additional ingredients, such as fillers or additives, that may cause adverse reactions or interfere with absorption.

5. Price: While price is not the most important factor, it is important to choose a supplement that is within your budget and provides good value for money.

By considering these factors, you can select a methylfolate supplement that will effectively support your MTHFR gene and overall health.

What are the top-rated methylfolate supplements for individuals with the MTHFR gene mutation?

There are several top-rated methylfolate supplements for individuals with the MTHFR gene mutation. Some of the most popular ones include Thorne Methyl-Guard Plus, Seeking Health Optimal Multivitamin, Pure Encapsulations MethylAssist, and Jarrow Formulas Methyl B-12. These supplements contain methylfolate, which is the active form of folate that can be easily absorbed and utilized by the body. They also often include other essential vitamins and minerals such as B12, B6, and magnesium, which can support healthy methylation and overall health. It's important to consult with a healthcare professional before starting any supplement regimen, especially if you have a known MTHFR gene mutation or other health conditions. They can help determine the appropriate dosage and monitor for any potential side effects or interactions with other medications.

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