20 Best Enzyme Cleaner For Pet Urine (2023 Updated)

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Enzyme cleaners are specifically designed to break down the components of pet urine, making it easier to clean and remove the odor. Enzymes work by breaking down the urine into simpler molecules, which are then more easily removed by regular cleaning products.

20 Best Enzyme Cleaner For Pet Urine

Product Image Product Name Features Price

OdoBan Pet Solutions Stain Remover, Pet, Oxy – 1 qt

  • OdoBan Pet Oxy Stain remover safely removes stain from surfaces with the power of oxygen
  • Removes stains and odors from urine, vomit, feces, blood, dirt and grass

Bissell Professional Pet Urine Elimator with Oxy and Febreze Carpet Cleaner Shampoo

  • 2X concentrated formula for use in all upright carpet cleaning machines
  • Removes pet stains and odors at the source with the power of oxy and febreze freshness

OdoBan Pet Oxy Stain Remover and Odor Eliminator, 32 fl oz, 4 Pack, 4 Count

  • Multi-Surface: Our Ready-to-Use formula can be used on many surfaces that your pet may come in contact with including carpet, fabric, and upholstery.

Nature's Miracle Simply Pet Stain and Odor Remover, 128 fl. oz., 128 FZ

  • MADE WITH 86% PLANT-DERIVED SURFACTANTS: Simply Nature’s Miracle Pet Stain and Odor Remover features formulas made with 86% plant-based surfactants

Equalizer Carpet Stain & Odor Eliminator, 20 oz

  • Best solution for urine, feces, blood and vomit stain remover, works in seconds to clean your carpet.
  • Quick, easy mess eliminator – simply spray cleaner to remove odors and stains; no scrubbing needed!

Bissell 2X Pet Stain & Odor Carpet Shampoo – 24 fl oz jug

  • PET INSPIRED stain remover for use in all full-sized deep cleaning machines on carpet and upholstery.
  • Patented odor control technology removes odors and neutralizes general pet odors.

Shout Carpet Cleaner Oxy Urine Destroyer – 32 fl oz bottle

  • REMOVES PET STAINS AND ELIMINATES ODORS —Pet stain remover is designed to work deep down in the fabric to eliminate all traces of your pet’s mishap

Bissell 1129 Pet Pretreat + Sanitize Stain & Odor Remover

  • Bottle is factory sealed.
  • Someone wrote “B Acid” on the top of the cap.

Biokleen Bac-Out Stain+odor Remover, Destroys Stains & Odors Safely, for Pet …

  • Destroys stains and odors safely and naturally with an unique blend of live enzyme cultures, botanicals, and plant-based surfactants

Skout's Honor Urine Destroyer – Carpet Pad Penetrator 32-oz

  • Professional Strength
  • Permanently removes stains
  • Destroys odor molecules

Bissell Stain & Stink Remover, Oxy – 22 fl oz

  • Pherobloc technology discourages pets from resoiling the same spot
  • Works on both old and new stains
  • Fast-acting to remove colored stains from feces or vomit caused by dyes in pet food

Biokleen Bac-Out Stain & Odor Remover-128 oz.

  • Destroys the toughest odors so they are gone for good.
  • Kind to those with chemical sensitivities and allergies.
  • Bac-Out is safe to use around children and pets, even birds.

Bissell Advanced Pet Stain & Odor Remover, 32 oz, Size: 32 fl oz

  • Removes tough pet stains and odours
  • Patented odour eliminator
  • EPA design for the Environment Certification
OdoBan Pet Solutions Stain Remover, Pet, Oxy – 1 qt
  • OdoBan Pet Oxy Stain remover safely removes stain from surfaces with the power of oxygen
  • Removes stains and odors from urine, vomit, feces, blood, dirt and grass
Bissell Professional Pet Urine Elimator with Oxy and Febreze Carpet Cleaner Shampoo
  • 2X concentrated formula for use in all upright carpet cleaning machines
  • Removes pet stains and odors at the source with the power of oxy and febreze freshness
OdoBan Pet Oxy Stain Remover and Odor Eliminator, 32 fl oz, 4 Pack, 4 Count
  • Multi-Surface: Our Ready-to-Use formula can be used on many surfaces that your pet may come in contact with including carpet, fabric, and upholstery.
Nature's Miracle Simply Pet Stain and Odor Remover, 128 fl. oz., 128 FZ
  • MADE WITH 86% PLANT-DERIVED SURFACTANTS: Simply Nature’s Miracle Pet Stain and Odor Remover features formulas made with 86% plant-based surfactants
Equalizer Carpet Stain & Odor Eliminator, 20 oz
  • Best solution for urine, feces, blood and vomit stain remover, works in seconds to clean your carpet.
  • Quick, easy mess eliminator – simply spray cleaner to remove odors and stains; no scrubbing needed!
Bissell 2X Pet Stain & Odor Carpet Shampoo – 24 fl oz jug
  • PET INSPIRED stain remover for use in all full-sized deep cleaning machines on carpet and upholstery.
  • Patented odor control technology removes odors and neutralizes general pet odors.
Shout Carpet Cleaner Oxy Urine Destroyer – 32 fl oz bottle
  • REMOVES PET STAINS AND ELIMINATES ODORS —Pet stain remover is designed to work deep down in the fabric to eliminate all traces of your pet’s mishap
Bissell 1129 Pet Pretreat + Sanitize Stain & Odor Remover
  • Bottle is factory sealed.
  • Someone wrote “B Acid” on the top of the cap.
Biokleen Bac-Out Stain+odor Remover, Destroys Stains & Odors Safely, for Pet …
  • Destroys stains and odors safely and naturally with an unique blend of live enzyme cultures, botanicals, and plant-based surfactants
Skout's Honor Urine Destroyer – Carpet Pad Penetrator 32-oz
  • Professional Strength
  • Permanently removes stains
  • Destroys odor molecules
Bissell Stain & Stink Remover, Oxy – 22 fl oz
  • Pherobloc technology discourages pets from resoiling the same spot
  • Works on both old and new stains
  • Fast-acting to remove colored stains from feces or vomit caused by dyes in pet food
Biokleen Bac-Out Stain & Odor Remover-128 oz.
  • Destroys the toughest odors so they are gone for good.
  • Kind to those with chemical sensitivities and allergies.
  • Bac-Out is safe to use around children and pets, even birds.
Bissell Advanced Pet Stain & Odor Remover, 32 oz, Size: 32 fl oz
  • Removes tough pet stains and odours
  • Patented odour eliminator
  • EPA design for the Environment Certification

1. OdoBan Pet Solutions Stain Remover, Pet, Oxy – 1 qt

OdoBan Pet Solutions Stain Remover, Pet, Oxy - 1 qt

  • OdoBan Pet Oxy Stain remover safely removes stain from surfaces with the power of oxygen
  • Removes stains and odors from urine, vomit, feces, blood, dirt and grass
  • Environmentally friendly formula is recognized for safer chemistry by the US EPA Safer Choice Program
  • Targets and neutralizes bad odors and smells in carpet- Targets and neutralizes bad odors and smells in fabric

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Product Details

Specifications

Details
Units in Package 1
Unit Size 1 qt
Directions Direction for Use: Scoop up any thick soil with a spoon or dull knife. Blot up any wet soil with a clean colorfast cloth, sponge or paper towel. Spray directly on stain. Immediately blot with a clean absorbent, colorfast cloth or paper towel. Repeat as necessary. For carpet, vacuum to restore carpet pile after it is dry. Note: Test a hidden area of carpet or fabric for colorfastness. Allow test area to dry. If color bleeds or discolors, fabric or carpet is not colorfast.
Warnings Caution: See side panel. Eye irritant. Keep out of reach of children. Caution – May be harmful if inhaled or swallowed. Causes eye irritation. Avoid contact with eyes or skin. Wash hands with soap and water after handling. Contact on burned or open skin may cause stinging. For prolong use, wear gloves. Use in well-ventilated areas and avoid inhaling mist. If In Eyes: Flush with plenty of water. Call a physician if irritation persists. Contains hydrogen peroxide. For more information on ingredients visit http://cleancontrol.com/saferchoice.

Reviews From Real Customers

Handy 604 Man
Debra
Momma G

2. Hoover Paws & Claws Urine Eliminator Spray, Pet Spot and Stain Remover, 22oz …

Hoover Paws & Claws Urine Eliminator Spray, Pet Spot and Stain Remover, 22oz ...

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Product Details

Specifications

Details
Product Dimensions 4.75 x 4.5 x 10.63 inches
Country of Origin USA
Specific Uses For Product Upholstery,Car
Volume 22 Fluid Ounces
Scent Fresh
Unit Count 1.0 Count
Surface Recommendation Upholstery, Carpet
Contains Liquid Contents Yes

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MPotter825
Annie42
DennyP

3. Bissell Professional Pet Urine Elimator with Oxy and Febreze Carpet Cleaner Shampoo

Bissell Professional Pet Urine Elimator with Oxy and Febreze Carpet Cleaner Shampoo

  • 2X concentrated formula for use in all upright carpet cleaning machines
  • Removes pet stains and odors at the source with the power of oxy and febreze freshness
  • Cleans and protects from future stains with scotch gard protector. Surface Type – Heavy Traffic Areas, Large Area
  • Contains no heavy metals, phosphates or dyes. Biodegradable detergents
  • Pet and family safe when used as directed

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Product Details

Specifications

Details
Country of Origin – Textiles USA and Imported
Is Pet Friendly Y
Contained Battery Type 1
Multipack Quantity 1
Piece Count 1
Count Per Pack 1
Clock Dial Number Type California
Assembled Product Weight 48 oz
Assembled Product Dimensions (L x W x H) 2.72 x 5.98 x 10.98 Inches
Count 1

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JG2016
Barry

4. OdoBan Pet Oxy Stain Remover and Odor Eliminator, 32 fl oz, 4 Pack, 4 Count

OdoBan Pet Oxy Stain Remover and Odor Eliminator, 32 fl oz, 4 Pack, 4 Count

  • Multi-Surface: Our Ready-to-Use formula can be used on many surfaces that your pet may come in contact with including carpet, fabric, and upholstery.
  • Residue-Free: Our Oxy Stain Remover leaves no sticky residue behind, so you can be sure to have a clean slate again once the treated area is all dry.

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Product Details

Specifications

Details
Is Discontinued By Manufacturer No
Product Dimensions 13.5 x 10 x 8 inches; 4 Ounces
Country of Origin USA
Unit Count 4.0 Count
Surface Recommendation Fabric
Special Feature Residue free
Special Ingredients Hydrogen Peroxide
Contains Liquid Contents No

5. Nature’s Miracle Simply Pet Stain and Odor Remover, 128 fl. oz., 128 FZ

Nature's Miracle Simply Pet Stain and Odor Remover, 128 fl. oz., 128 FZ

  • MADE WITH 86% PLANT-DERIVED SURFACTANTS: Simply Nature’s Miracle Pet Stain and Odor Remover features formulas made with 86% plant-based surfactants
  • FORMULATED WITHOUT: Parabens, phthalates, phosphates and added dyes
  • BIO-ENZYMATIC FORMULA: Tough on pet messes like urine, feces, vomit, drool and other organic stains and odors
  • PET ODOR CONTROL FORMULA: The Odor Capture 360 formula controls pet odors and freshens with essential oils for a pleasant scent
  • SAFE FOR PETS AND HOME: When used and stored as directed, this product is safe for pets and home. It’s tough on pet messes but not on your floor

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Product Details

Specifications

Details
Primary Brand Nature’s Miracle
Scented No
Length 5.098 IN
Volume 128 FZ

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Air Care Deodorizer

6. Bissell Home care Pet stain and odor Formula – 16 fl oz bottle

Bissell Home care Pet stain and odor Formula - 16 fl oz bottle

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Product Details

Specifications

Details
Compatible Models Bissell
Count 1
Multipack Quantity 1
Video Game Platform PC
Recommended Surface Carpet
Count Per Pack 1
Household Cleaner Type Carpet & Rug Cleaners
Form Liquids
Container Type Bottle
Applicator Type NOT STATED
Animal Type Cat

Reviews From Real Customers

Michael
Dani00
Cheryl

7. Equalizer Carpet Stain & Odor Eliminator, 20 oz

Equalizer Carpet Stain & Odor Eliminator, 20 oz

  • Best solution for urine, feces, blood and vomit stain remover, works in seconds to clean your carpet.
  • Quick, easy mess eliminator – simply spray cleaner to remove odors and stains; no scrubbing needed!
  • Safely use pet odor remover on carpet, rugs, furniture, pet beds, crate pads, car interiors & more.
  • Recommended for dog & cat house training, sick or elderly pets, behavioral or territorial problems.
  • Formulated in the USA by trusted veterinarians dedicated to your dog and cat’s health and wellbeing.

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Specifications

Details
Weight 24.64 oz

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Nancy F L

8. Nature’s Miracle Cat Urine Stain Remover | P-98361

Nature's Miracle Cat Urine Stain Remover | P-98361

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Product Details

Specifications

Details
Scent No
Form Spray
Removes Urine Yes
Package Quantity 1
All-Natural Ingredients Yes
Odor Blocking Yes

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Tbit
Jesse M
Mack

9. Bissell 2X Pet Stain & Odor Carpet Shampoo – 24 fl oz jug

Bissell 2X Pet Stain & Odor Carpet Shampoo - 24 fl oz jug

  • PET INSPIRED stain remover for use in all full-sized deep cleaning machines on carpet and upholstery.
  • Patented odor control technology removes odors and neutralizes general pet odors.
  • Works to loosen and remove stains, and discourages pets from soiling in the same area.
  • Contains Scotchgard Protector to help protect carpet from future stains.
  • 2x concentrated formula means you only need to use half as much. Made in the USA with an EPA-certified design.

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Product Details

Specifications

Details
Manufacturer Part Number 99K5
Product Name Surface Cleaner
Packaged Quantity 6 Pack
Product Type Surface Cleaner
Product Information
Cleaner Type Liquid
Cleaner Volume 24 fl oz (0.8 quart)
Scent Fresh
Recommended Use Stain Remover,Odor Remover,Soil Remover,Pet Dander Remover,Dirt Remover
Miscellaneous
Certifications & Standards EPA

10. Shout Carpet Cleaner Oxy Urine Destroyer – 32 fl oz bottle

Shout Carpet Cleaner Oxy Urine Destroyer - 32 fl oz bottle

  • REMOVES PET STAINS AND ELIMINATES ODORS —Pet stain remover is designed to work deep down in the fabric to eliminate all traces of your pet’s mishap
  • POWERFUL ON STAINS — Carpet stain remover is powerful on set in stains while being gentle on your carpets and furniture
  • CONTAINS OXY — Stain remover for carpet uses the power of oxygen to target stains and odors to clean completely down to the fabric subsurface
  • PREVENTS REMARKING — Carpet cleaner goes to work on odors as well as stains to completely eliminate all evidence and prevent re-marking

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Product Details

Specifications

Details
Fluid Ounces 32 oz
Items Included 32 FL OZ (946 mL)
Product Net Content UOM Fluid Ounces
Multipack Quantity 1
Scent Oxy Fresh
Recommended Room Kids Room
Piece Count 6
Recommended Surface Floor
Count Per Pack 1
Recommended Location Indoor
Household Cleaner Type Floor Cleaners
Form Liquids
Container Type Bottle
Applicator Type NOT STATED

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SOPHIA
Satisfied

11. Bissell 1129 Pet Pretreat + Sanitize Stain & Odor Remover

Bissell 1129 Pet Pretreat + Sanitize Stain & Odor Remover

  • Bottle is factory sealed.
  • Someone wrote “B Acid” on the top of the cap.

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Specifications

Details
Manufacturer Part Number 011120185720
Product Model 1129
Product Name Pet Pretreat + Sanitize Stain & Odor Remover for Carpet | 1129
Packaged Quantity 1
Product Type Pet Stain/Odor Remover
Product Information
Recommended Use Bacteria Remover,Dirt Remover,Stain Removal,Odor Removal

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Sharon
Petmom

12. Biokleen Bac-Out Stain+odor Remover, Destroys Stains & Odors Safely, for Pet …

Biokleen Bac-Out Stain+odor Remover, Destroys Stains & Odors Safely, for Pet ...

  • Destroys stains and odors safely and naturally with an unique blend of live enzyme cultures, botanicals, and plant-based surfactants
  • Full Strength Formula is ready to use – No diluting required
  • Eco-Friendly, Non-Toxic, Plant-Based, No Artificial Fragrance, Colors or Preservatives
  • Great on pet accidents, wine, diapers, laundry, drains, carpets, and much more
  • Kind to those with chemical sensitivities and allergies

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Product Details

Specifications

Details
Animal Type Dog

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Karen

13. Skout’s Honor Urine Destroyer – Carpet Pad Penetrator 32-oz

Skout's Honor Urine Destroyer - Carpet Pad Penetrator 32-oz

  • Professional Strength
  • Permanently removes stains
  • Destroys odor molecules
  • Helps prevent re-soiling

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Product Details

Specifications

Details
Primary Brand Skout’s Honor
Scented No
Length 3 IN
Volume 32 FZ

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Amanda D.
AmandaSD

14. Bissell Advanced Professional Pet Urine Eliminator with OXY, 50 oz

Bissell Advanced Professional Pet Urine Eliminator with OXY, 50 oz

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Product Details

Specifications

Details
Count 1
Multipack Quantity 1
Scent Unscented
Recommended Surface Carpet
Is Portable Y
Count Per Pack 1
Recommended Location Indoor
Animal Type Cat
Fluid Ounces 50 oz
Compatible Models Bissell
Recommended Room Kids Room
Recommended Use Residential
Is Unscented Y
Compatible Devices Vacuum
Household Cleaner Type Carpet & Rug Cleaners
Form Liquids
Number of Stages 1-Stage

15. Bissell Stain & Stink Remover, Oxy – 22 fl oz

Bissell Stain & Stink Remover, Oxy - 22 fl oz

  • Pherobloc technology discourages pets from resoiling the same spot
  • Works on both old and new stains
  • Fast-acting to remove colored stains from feces or vomit caused by dyes in pet food
  • Country of Origin: United States

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Product Details

Specifications

Details
Units in Package 1
Unit Size 22 fl oz
Directions How to Use: Before cleaning: Test a small, hidden area for colorfastness and examine when dry. If color is affected, do not use. For upholstery, look for manufactures cleanability code tag. Use on fabric coded ‘WS’ or ‘W’. If coded ‘X’ or ‘S’ do not use. Not recommended for use on velvet, silk or leather upholstery. 1. Remove solid particles or excess liquid. 2. Shake well, turn nozzle to spray position and saturate soiled and surrounding area. 3. Let sit for 5-10 minutes to penetrate stain. 4. Blot with dry, color-safe cloth to remove stain and absorb as much as possible. 5. Rinse and repeat as needed (Treat stains immediately for best results as some stains may cause permanent discolorations over time). 6. Pet-safe when used as directed. Stay off and keep pets off cleaned area until dry and vacuumed.
Warnings Avoid eye contact. In case of eye contact, flush thoroughly with water for at least 15 minutes. Get medical attention if irritation develops or persists. Keep out of reach of children and pets.

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Joanne

16. Urine Remover for Stains and Odors, 32 oz Pull Top Bottle, 6-carton

Urine Remover for Stains and Odors, 32 oz Pull Top Bottle, 6-carton

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Diana

17. Biokleen Bac-Out Stain & Odor Remover – 32 oz

Biokleen Bac-Out Stain & Odor Remover - 32 oz

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Product Details

Specifications

Details
Units in Package 1
Unit Size 32 oz
Directions Directions for Use: To remove stains + odors , remove excess waste, saturate affected area, let sit for 5 minutes or more. Blot with rag. Repeat process if needed. Does not need to be rinsed. Try Bac-Out on pet accidents, carpet, wine, diapers and pails, laundry, disposals, garbage cans and more.
Ingredients Water (Filtered), Glycerin (Vegetable), Caprylyl/Capryl Glucoside (Plant Based Surfactant), C10-16 Alkyl Glucoside (Plant Based), Laureth 7 (Plant Based Surfactant), Citrus Terpenes, Dipropylene Glycol, Benzisothiazolinone, Viable Bacillus Cultures.
Warnings Keep out of reach of children. Caution: In case of eye contact, flush with cool water for 15 minutes. In case of ingestion, do not induce vomiting; drink plenty of water to dilute.

18. Biokleen Bac-Out Stain & Odor Remover-128 oz.

Biokleen Bac-Out Stain & Odor Remover-128 oz.

  • Destroys the toughest odors so they are gone for good.
  • Kind to those with chemical sensitivities and allergies.
  • Bac-Out is safe to use around children and pets, even birds.
  • No artificial fragrance or colors.

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Product Details

Specifications

Details
Pack Size 128 OZ

19. Nature’s Miracle Dog Urine Remover – 24 fl oz

Nature's Miracle Dog Urine Remover - 24 fl oz

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Product Details

Specifications

Details
Removes Urine Yes
Scent Yes
Form Spray
All-Natural Ingredients Yes
Odor Blocking No
Package Quantity 1

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Callmemrsgallego

20. Bissell Advanced Pet Stain & Odor Remover, 32 oz, Size: 32 fl oz

Bissell Advanced Pet Stain & Odor Remover, 32 oz, Size: 32 fl oz

  • Removes tough pet stains and odours
  • Patented odour eliminator
  • EPA design for the Environment Certification
  • Safe for use in portable carpet cleaning machines
  • 2X concentration so you can use half as much

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Product Details

Specifications

Details
Items Included 32 FL OZ (1QT) 946mL
Count 1
Multipack Quantity 1
Scent Fresh
Recommended Room Kids Room
Is Unscented Y
Recommended Surface Carpet
Count Per Pack 1
Recommended Location living rooms, car, Indoor
Compatible Devices Vacuum
Household Cleaner Type Carpet & Rug Cleaners
Form Liquids
Container Type Bottle
Applicator Type NOT STATED
Animal Type Cat, Dog
Assembled Product Weight 2.38 lbs
Assembled Product Dimensions (L x W x H) 2.63 x 4.63 x 9.38 Inches

Conclusion

After testing several enzyme cleaners for pet urine, we have concluded that the best product on the market is the Pet Stain and Odor Remover by Rocco & Roxie Supply Co. This cleaner is specifically designed to remove pet stains and odors, and it does an excellent job of both.

It is also safe to use around children and pets, and is gentle on carpets and upholstery.

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